Nitric Oxide Generating Formulation as an Innovative Approach to Topical Skin Care: An Open-Label Pilot Study

Nitric oxide (NO) plays multiple roles in both normal and abnormal skin processes. Its deranging disbalance is involved the pathogenesis of dermatologic diseases such as acne vulgaris, pointing towards beneficial therapeutic directions. A novel NO-producing gel-formulation was tested treatment vulgaris an open-label pilot study using clinical evaluation scores. It showed a decrease comedones inflammatory pustulae reduced Global Acne Grading System score by 50% within eight weeks. In addition, we demonstrate potential use cosmetic agent where NO therapy leads to increase integrity reduction ageing